SERUM URIC ACID LEVELS AND RELATED FACTORS IN CHRONIC KIDNEY DISEASE

Abstract

Introduction: The end product of purine metabolism, uric acid (UA), excreted mainly by the kidneys through tubular transporters is associated with hypertension, ischemic heart disease, cerebrovascular disease, metabolic syndrome, gout, chronic and acute kidney disease (CKD). Accumulating evidence suggests that hyperuricemia is not only a result but also a risk factor for CKD. UA levels are increasing since the early stages of CKD and elevated UA levels are associated with cardiovascular morbidity and mortality.In this study, we aimed to quantify UA levels in patients diagnosed with CKD and to correlate results with the other associated factors. Material And Method: In this study 270 patients diagnosed with CKD was screened. Two groups assessed; these were the group-1 with the glomerular filtration rate (eGFR) 60 ml/min1.73m2 or below and the group-2 with the eGFR above 60 ml/min. Demographic characteristics, systolic-diastolic blood pressure (SBP, DBP), mean arterial pressure (MAP), urea, creatinine, UA, leukocyte count, neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), albumin, proteinuria and microalbuminuria in 24-hour urine were determined. Between the two groups we compared all these parameters statistically and their correlation with the serum UA. Results: Demographic datas such as age and gender was found statistically insignificant. There was significant difference in means of DBP between the two groups. Mean serum UA showed statistically significant difference. NLR, CRP, albumin, proteinuria and microalbuminuria also showed statistically significant difference between the two groups. Conclusion : Increased serum UA levels in CKD patients is directly associated with proteinuria, microalbuminuria, inflammation and DBP. Therefore, considering the effect of increased the serum UA levels on these factors, our one of the main therapeutic target should aim to decrease the serum UA levels.