A Study of Serum Uric Acid Levels in Acute Ischemic Stroke Patients Admitted in Tertiary Care Hospital At Tirupati

Abstract

It is unclear whether Serum Uric Acid (SUA) promotes or protects against cerebrovascular disease. Present study was done to estimate uric acid levels and its association in patients of acute ischemic stroke. Method: Total 100 consecutive patients (50 males and 50 females) with first episode of stroke as evidenced by CT scan within 48 hours were chosen for the study .The serum uric acid was estimated by the Uricase method. The patients were further evaluated for the presence of additional risk factors like hypertension, diabetes mellitus, coronary heart disese (CAD),smoking and alcoholism. Results: Out of total 100 patients, 50 were males and 50 were females. The age of the patients in the present study were from 40 years to 84 years with mean age of 59.8 years. Mean serum uric acid level in patients were studied 5.58±1.68 mg/dl and about 25% patients were hyperuricemic. As age advances the uric acid level also rised with the ' p ' of < 0.001. Among diabetics the mean uric acid value was 6.12± 1.64 mg/dl while among non diabetics it was 5.02± 1.54 mg/dl, among in CAD patients it was 6.5± 1.9 mg/dl and in those without CAD was 5.1 ± 1.4 mg/dl; Among the patients with large infarct was 7.2 mg/dl compared to those with small infarct was 4.816 mg/dl and thus established a statistically significant relationship (p value of < 0.0001). The present study didnt show any significant association between hypertension, hyperlipidemia, smoking, alcoholism and uric acid. Conclusions: The prevalence of hyperuricemia in acute ischemic stroke patients in the present study was 25%. There was a statistically significant association between levels of uric acid and age, diabetes mellitus, CAD, larger infarct size. There was no stastically a signicant association between hypertension, hyperlipidemia, smoking, alcoholism and uric acid levels.