Serum Uric Acid Is Significantly Related to the Components of the Metabolic Syndrome in Japanese Workingmen

Abstract

The aim of this study was to examine whether serum uric acid (SUA) concentration was related to the metabolic syndrome (MS). A total of 981 Japanese workingmen were studied. MS was diagnosed based on the modified criteria of the International Diabetes Federation. MS was present in 8.0% of the target participants. Logistic regression analysis using a cutoff value of the SUA of 7.0 mg/dL showed that some components of MS and the logarithmic value of the serum C-reactive protein were associated with a significant odds ratio for predicting elevated SUA. The odds ratios and 95% confidence intervals (CIs) of a high logarithmic value of the serum C-reactive protein, large waist girth, elevated blood pressure, and dyslipidemia for elevated SUA were 1.76 (CI, 1.21-2.55), 1.72 (CI, 1.21-2.45), 1.42 (CI, 1.01-2.00), and 1.87 (CI, 1.30-2.69), respectively. Most of the components of MS were significant determinants of SUA.