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Abstract
The purpose of this study was to estimate and compare the levels of tissue non-specific alkaline phosphatase isoenzyme in serum of healthy individual and in chronic periodontitis patients with varying severity. Serum samples were obtained from 31individuals. 10 from healthy individuals and 21 from chronic periodontitis patients categorized as mild, moderate and severe based on CAL values. The samples were used to determine the Tissue Non – Specific Alkaline Phosphatase Isoenzyme (TNSALP) level. Evaluation and comparison of the tissue non – specific alkaline phosphatase isoenzyme activity between the control and chronic periodontitis patient group showed a decrease in bone type of tissue non – specific alkaline phosphatase level among mild, moderate and severe chronic periodontitis patients group. The steady decrease in Bone type of TNSALP might help to provide useful information if monitored successively over a period of time. Keywords: Alkaline Phosphatase Isoenzyme, Chronic Periodontitis, Severity of Chronic Periodontitis, Serum Enzymatic Assay, Tissue Non-Specific Alkaline Phosphatase Isoenzyme, TNSALP.
Highlights
Chronic periodontitis is a longstanding inflammatory disease affecting the supporting structures of the dentition namely the gingiva, periodontal ligament, cementum and adjacent surrounding alveolar bone
The subgroup B3 categorized as severe periodontitis patients has a mean of 24.329 ± 0.547 bone type of tissue non-specific alkaline phosphatase isoenzyme in serum
The tissue non-specific isoenzyme of alkaline phosphatase was analyzed in both healthy individuals and in persons diagnosed as chronic periodontitis
Summary
Chronic periodontitis is a longstanding inflammatory disease affecting the supporting structures of the dentition namely the gingiva, periodontal ligament, cementum and adjacent surrounding alveolar bone. Most routine methods to diagnose chronic periodontitis is by clinical evaluation of affected site and measuring the attachment loss followed by radiographic confirmation by identifying bone loss. These methods do not shed light on the status of progression or regression occurring in the diseased sites and fail to identify newly developing disease sites[1,2]. For better evaluation of prognosis and effective treatment, it is important to identify the current status of the disease. Changes at both cellular levels and sub – cellular levels show us the current status of the disease and are evaluated or identified using biochemical assay.
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