Abstract
Mycoplasma pneumoniae pneumonia (MPP) is an acute respiratory tract infection caused by Mycoplasma pneumoniae. It is characterized by severe symptoms, long course of disease, many intrapulmonary complications, and poor therapeutic effect. In recent years, the incidence of Mycoplasma infection have been gradually rising trend, and the children's own immune system development is not mature, cases differences, children with mild can only show the upper respiratory tract infection, and critically ill children can lead to lung infection and even lead to multiple organ dysfunction, affect life and health of children. Soluble triggering receptors expressed on myeloid cell-1 (sTREM-1) is a subtype secreted by myeloid cell trigger receptor-1, which is released into blood in large amounts when the body is infected, and is a newly discovered inflammatory indicator in recent years. CXC chemokine 16 (CXCL-16) can recruit lymphocytes by chemotaxis through binding to its receptor CXCR6 to participate in the body's immune regulation. The purpose of this study was to investigate serum sTREM-1 and CXCL-16 levels in children with MPP and to analyze their correlation with the disease and diagnostic value. The results showed that the serum levels of sTREM-1 and CXCL-16 were increased in children with Mycoplasma. Serum levels of sTREM-1 and CXCL-16 were positively correlated with the severity of the disease. sTREM-1 combined with CXCL-16 has an important value in the diagnosis of children with MPP.
Highlights
Pneumonia is one of the common pediatric diseases and the primary cause of death of hospitalized children in China [1, 2]
Mycoplasma pneumoniae pneumonia (MPP) is an acute respiratory infection caused by Mycoplasma pneumoniae, accounting for 10–30% of bronchopneumonia [5, 6]
Ere are many methods for diagnosis of MPP infection, among which the isolation and culture of Mycoplasma pneumoniae is a reliable standard for diagnosis of MPP infection
Summary
Pneumonia is one of the common pediatric diseases and the primary cause of death of hospitalized children in China [1, 2]. Nucleic acid diagnostic technology has strong specificity, high sensitivity, and rapid and can be used for early diagnosis, but the technical requirements are high, and it is easy to be affected by the carrying state after MPP infection, so it is not applicable to clinical practice [2, 11]. At present, methods such as lung X-rays and detection of Mycoplasma IgM antibodies are often used in clinical practice.
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