Effect of soluble triggering receptor expressed on myeloid cells-1 on extravascular lung water in patients with acute respiratory distress syndrome

Abstract

Objective To analyze the effect of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1)on extravascular lung water in patients with acute respiratory distress syndrome. Methods Fifty-three patients with acute respiratory distress syndrome admitted to ICU ward in our hospital from October 2016 to October 2017 were selected as the research object.The level of serum sTREM-1 was measured on the first day, the third day and the seventh day after admission. The changes of extravascular lung water index and pulmonary vascular permeability index were monitored with PICCO monitor during the same period.The patients were divided into survival group and death group according to their survival after two weeks of admission. The serum levels of sTREM-1 and the changes of ELWI and PVPI were compared between the two groups. Results Among the 53 patients, 29 survived and 24 died after two weeks of admission. There was no significant difference in serum sTREM-1 level between the survival group and the death group on the first day after admission (P> 0.05). Compared with the death group, serum sTREM-1 levels in the survival group were significantly decreased on the 3rd and 7th days after admission (P 0.05). There was significant difference between ELWI and PVPI on the 3rd and 7th day after admission (P <0.05). After admission, the ELWI and PVPI in survivors increased first and then decreased, and there was significant difference between the groups (P <0.05). ELWI and PVPI in the death patients increased gradually after admission, and there was significant difference between the groups(P <0.05); Pearson correlation analysis suggested that serum sTREM-1 levels were correlated with the ELWI and the PVPI (r = -0.518/-0.476, P = 0.007/0.022). Cox regression analysis suggested that serum sTREM-1 levels, ELWI, and PVPI were risk factors for the prognosis of patients with acute respiratory distress syndrome (P<0.05). Conclusions Serum levels of sTREM-1 in patients with acute respiratory distress syndrome are positively correlated with extravascular lung water, and sTREM-1 may have some impact on extravascular lung water, which may be one of the evaluation indexes for judging the prognosis of patients with acute respiratory distress syndrome. Key words: Acute respiratory distress syndrom; Soluble triggering receptor expressed on myeloid cells-1; Extravascular lung water