Abstract
Serum somatomedin activity (SSA) was measured by incorporation of 35 S in pork rib cartilage in 26 obese children, 9 boys and 17 girls, aged 7 to 15 years, whose weight excess ranged from 45 to 100%, and in 15 normal children of comparable ages. The SSA mean value was 0.96 in obese children, identical to that of controls (0.98), despite lower serum growth hormone levels after arginine in obese children. However, the range of individual values was wider in obese subjects. No inhibitory effect was found with low SSA obese serum on SSA of normal human serum. A significant (p<0.001) negative correlation was found between SSA and weight excess in obese children (y = −0.01 x + 1.60, r = 0.7109). These data demonstrate that 1/ SSA is normal in most obese children despite low serum growth hormone levels 2/ SSA is negatively correlated to the weight excess.
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