Abstract
Serum sodium trajectory during AKI and mortality risk.
Highlights
Kidneys play a primary role in electrolyte homeostasis
It has previously been observed that patients with Acute kidney injury (AKI) who had dysnatremia at hospital admission had a higher risk of death [13]
Study Design and Patient Population. In this prospective cohort study, we enrolled patients admitted to the Civil Hospital of Guadalajara Fray Antonio Alcalde, Mexico, from August 2017 to March 2020
Summary
The association between serum sodium level and mortality or the need for kidney replacement therapy during acute kidney injury has not been adequately explored. Serum sodium (sNa) levels during AKI is common [3, 4]. It is not surprising to dysnatremias, defined as hyponatremia (plasma sodium < 135 mmol/L) [6], hypernatremia (plasma sodium > 145 mmol/L) [7, 8], and fluctuations in sNa [9], to be associated with complications during hospitalization, including the risk of death [10, 11]. It has previously been observed that patients with AKI who had dysnatremia (sNa < 135 or > 145 mmol/L) at hospital admission had a higher risk of death [13]. This study investigates the association between the trajectory of sNa during the hospitalization among patients with AKI and their outcomes. We hypothesize that the sNa fluctuations are related to the higher probability of death and KRT initiation
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