Acute kidney injury predicts mortality in emergency general surgery patients

Abstract

BackgroundPatients undergoing Emergency General Surgery (EGS) have increased risk of complications and death. The risk of AKI in patients undergoing EGS, along with associated outcomes, is unknown. MethodsThis two-institution observational study included adults admitted to intensive care units between 1997 and 2012. EGS was defined by 7 procedures occurring within 48 hours of ICU admission. The main outcome studied was AKI within 5 days, along with 90-day mortality. ResultsIn our cohort of 59,604 patients, 1758 (2.9%) underwent EGS. Risk of AKI in EGD patients was significantly increased relative to non-EGS patients, with adjusted odds of 1.7 (95%CI 1.40–1.94; P < 0.001). Risk of renal replacement for EGS patients was also increased, with odds of 1.8 (95%CI 1.37–2.46; P < 0.001). EGS patients were at significantly higher risk of 90-day mortality, with adjusted odds of 3.1 (95%CI 2.16–4.33,p < 0.001) for AKI and 4.5 (95%CI 2.58–7.96,p < 0.001) for AKI requiring renal replacement, relative to the absence of AKI. ConclusionsEGS is a robust risk factor for AKI in critically ill patients, the development of which is strongly predictive of increased 90-day mortality.