Abstract
BackgroundOmega-3 polyunsaturated fatty acids (PUFAs) produce lipid mediators with both anti-inflammatory and pro-resolution properties, including resolvins. The purpose of this study was to detect serum resolvin E1 (RVE1) levels in Hashimoto’s thyroiditis (HT) patients and healthy controls (HCs) and to evaluate the relationship of RVE1 with thyroid autoimmunity.MethodsA total of 57 participants were recruited, including 30 untreated HT patients and 27 age- and sex‐matched HCs. The levels of RVE1 in serum were measured via enzyme-linked immunosorbent assay (ELISA). An electrochemiluminescence immunoassay was used for the measurement of thyroid-stimulating hormone (TSH), total T4 (TT4), TT3, free T4 (FT4), FT3, anti-thyroid peroxidase antibody (TPOAb) and anti-thyroglobulin antibody (TgAb) levels. Hemogram tests and routine biochemical analyses were performed on each sample.ResultsThe serum level of RVE1 of HT patients (24.09, 15.76–34.38 pg/mL) was significantly lower than that of healthy controls (28.51, 20.76–51.23 pg/mL) (P = 0.027). RVE1 levels showed a downward trend with increasing TgAb levels (P for trend = 0.001). Multivariable ordinal logistic regression analysis showed that RVE1 levels were negatively correlated with increasing TgAb levels in both the unadjusted (OR = 0.9446, 95 % CI = 0.9111–0.9782, P = 0.002) and adjusted models (OR = 0.9380, 95 % CI = 0.8967–0.9811, P = 0.005).ConclusionsDecreased RVE1 levels might be a sign that HT is associated with inflammatory resolution dysfunction. RVE1 may serve as a protective factor against increased TgAb levels.
Highlights
Hashimoto’s thyroiditis (HT), which is known as chronic lymphocytic thyroiditis, is considered the most common autoimmune disease
HT Hashimoto’s thyroiditis; TT4 total T4; TT3 total T3; FT3 free T3; FT4 free T4; TSH thyroid-stimulating hormone; thyroid peroxidase antibody (TPOAb) anti-thyroperoxidase antibody; TgAb antithyroglobulin antibody; ALT alanine aminotransferase; AST aspartate aminotransferase; BUN blood urea nitrogen; TG triglyceride, TC total cholesterol; high-density lipoprotein (HDL) highdensity lipoprotein; LDL low-density lipoprotein; CRP C-reactive protein The standard reference range as follows: TgAb, 0-115 U/mL; TPOAb, 0‐34 U/mL; TT3, 0.61‐1.77 ng/mL; TT4, 5.13‐14.06 ug/dL; FT3, 3.10‐6.80 pg/mL; FT4, 12.00‐22.0 ng/dL; TSH, 0.027‐4.20 uIU/mL aThe results are expressed as means ± SD, bThe results are presented as medians
We found that serum resolvin E1 (RVE1) levels in the HT group was significantly lower than that in the control group, potentially indicating dysregulation of inflammation resolution in HT patients
Summary
Hashimoto’s thyroiditis (HT), which is known as chronic lymphocytic thyroiditis, is considered the most common autoimmune disease. HT is characterized by the production of autoantibodies against thyroid peroxidase (TPO) and thyroglobulin (Tg) in the serum and the presence of infiltrating lymphocytes in the thyroid. HT is currently considered an autoimmune disease affected by genetic and environmental factors. Among these factors, some nutritional factors have been confirmed to be related to HT, such as selenium and vitamin D [7, 8]. The purpose of this study was to detect serum resolvin E1 (RVE1) levels in Hashimoto’s thyroiditis (HT) patients and healthy controls (HCs) and to evaluate the relationship of RVE1 with thyroid autoimmunity
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