Abstract
BackgroundSubjects with higher carotid–femoral pulse wave velocity (cfPWV) will be at an increased risk for cardiovascular (CV) events in future. Resistin is an inflammatory mediator and a biomarker of CV diseases. We evaluated the association between serum resistin and aortic stiffness in patients with coronary artery disease (CAD).MethodsA total of 104 patients with CAD were enrolled in this study. cfPWV was measured using the SphygmoCor system. Patients with cfPWV >10 m/s were defined as the high aortic stiffness group.ResultsThirty-seven patients (35.6%) had high aortic stiffness and higher percentages of diabetes (p = 0.001), were of older age (p = 0.001) and had higher waist circumference (p < 0.001), systolic blood pressure (p = 0.027), pulse pressure (p = 0.013), high-sensitivity C-reactive protein (p < 0.001) and resistin levels (p < 0.001) but lower estimated glomerular filtration rate (p = 0.009) compared to subjects with low aortic stiffness. After adjusting for factors significantly associated with aortic stiffness by multivariate logistic regression analysis, serum resistin (odds ratio = 1.275, 95% confidence interval: 1.065–1.527, p = 0.008) was also found to be an independent predictor of aortic stiffness in patients with CAD.ConclusionsSerum resistin level is a biomarker for aortic stiffness in patients with CAD.
Highlights
Arterial stiffening due to loss of arterial compliance results in a more rapid travel time and a higher pulse wave velocity [1]
After adjusting for factors significantly associated with aortic stiffness by multivariate logistic regression analysis, serum resistin was found to be an independent predictor of aortic stiffness in patients with coronary artery disease (CAD)
Serum resistin level is a biomarker for aortic stiffness in patients with CAD
Summary
Arterial stiffening due to loss of arterial compliance results in a more rapid travel time and a higher pulse wave velocity [1]. A majority of epidemiological studies have demonstrated the predictive value of aortic stiffness as an independent predictor of cardiovascular (CV) morbidity and mortality by measuring the carotid–femoral pulse wave velocity (cfPWV), independent of traditional risk factors [2,3,4]. Our previous study noted serum leptin level could be a predictor for aortic stiffness in hypertensive patients [10]. We sought to examine the relationship between serum resistin levels and aortic stiffness in patients with CAD. Subjects with higher carotid–femoral pulse wave velocity (cfPWV) will be at an increased risk for cardiovascular (CV) events in future. We evaluated the association between serum resistin and aortic stiffness in patients with coronary artery disease (CAD)
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