SAT-211 SERUM ADIPOCYTE FATTY ACID BINDING PROTEIN LEVEL IS POSITIVELY ASSOCIATED WITH AORTIC ARTERIAL STIFFNESS IN CHRONIC KIDNEY DISEASE PATIENTS

Abstract

The adipocyte-fatty-acid-binding protein (A-FABP) plays a crucial role in development of insulin resistance and atherosclerosis by the interaction of metabolic and inflammatory pathways in adipocytes and macrophages. Chronic kidney disease (CKD) accelerates atherosclerosis via augmentation of inflammation, perturbation of lipid metabolism, and other mechanisms. The aim of this study was to evaluate the relationship between serum A-FABP levels and carotid-femoral pulse wave velocity (cfPWV) values in patients with CKD. Fasting blood samples and baseline characteristics were obtained from 270 patients with CKD (stage 1-5). Serum A-FABP concentrations were determined by enzyme immunoassay kit. High aortic stiffness was defined as carotid-femoral pulse wave velocity (cfPWV) values >10 m/s according to the ESH-ESC 2013 guidelines. Among 270 CKD patients, 92 patients (34.1%) were in the high aortic stiffness group. When compared to those in the low aortic stiffness group, the high aortic stiffness group had high prevalence of diabetes mellitus (P = 0.004), older age (P < 0.001), higher waist circumference (P = 0.004), body fat mass (P = 0.010), systolic blood pressure (P < 0.001), fasting glucose (P = 0.014), blood urea nitrogen (P = 0.009), creatinine (P = 0.004), and higher serum A-FABP level (P < 0.001), while lower estimated glomerular filtration rate (P = 0.001). Multivariable logistic regression analysis of the factors significantly associated with aortic stiffness revealed that A-FABP levels (odds ratio (OR): 1.174, 95% confidence interval (CI): 1.047–1.317, P = 0.006), age (OR: 1.062, 95% CI: 1.033–1.092, P = 0.001), and systolic blood pressure (OR: 1.017, 95% CI: 1.003–1.031, P = 0.015) were the independent predictors of aortic stiffness in CKD patients. Multivariable forward stepwise linear regression analysis also showed that A-FABP level (β = 0.178, P = 0.001) was an independent predictor of cfPWV values in CKD patients. There were significant increases in cfPWV values (P = 0.001) and serum A-FABP levels (P < 0.001) across increasing CKD stages. Elevated A-FABP concentration could be a predictor for aortic stiffness in patients with CKD. Increased CKD stages will elevate in cfPWV values and serum A-FABP levels.