Abstract
To establish serum protein fingerprint profile in patients with cicatricial airway stenosis and compared with healthy control. Serum samples of 17 cicatricial airway stenosis patients and 17 healthy persons were analyzed by SELDI-TOF-MS to select the differently expressed proteins through Biomarker Wizard software. Compared with healthy control, 49 protein biomarkers were identified. Among them, 25 proteins were up-regulated, 24 proteins were down-regulated. These proteins were confirmed by searching database. There are obvious differentially expressed proteins in patients with cicatricial airway stenosis and controls, which may related with the development of airway scar.
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