Abstract
Serum procalcitonin (PCT) and C-reactive protein (CRP) are biomarkers of infection. In patients with hematologic disorders with or without hematopoietic stem cell transplantation (HSCT), it is difficult to distinguish bloodstream infections from aseptic causes of febrile episodes. The objective of this study was to investigate diagnostic values of PCT and CRP in predicting systemic bacterial infection in patients with hematologic malignancies. Clinical and laboratory data of 614 febrile episode cases from 511 patients were analyzed. Febrile episodes were classified into four groups: (1) culture-positive bacterial infection by Gram-positive cocci (GPC), (2) culture-positive bacterial infection by Gram-negative bacilli (GNB), (3) fungal infection, and (4) viral infection or a noninfectious etiology. Of 614 febrile cases, systemic bacterial infections were confirmed in 99 (16.1%) febrile episodes, including 38 (6.2%) GPC and 61 (9.9%) GNB infections. PCT levels were significantly higher in GNB infectious episodes than those in febrile episodes caused by fungal infection (0.58 ng/mL (95% CI: 0.26-1.61) vs. 0.22 ng/mL (0.16-0.38), P = 0.047). Bacterial infectious episodes showed higher PCT and CRP levels than non-bacterial events (PCT: 0.49 (0.26-0.93) ng/mL vs. 0.20 (0.18-0.22) ng/mL, P < 0.001; CRP: 76.6 (50.5-92.8) mg/L vs. 58.0 (51.1-66.5) mg/L, P = 0.036). For non-neutropenic febrile episodes, both PCT and CRP discriminated bacteremia from non-bacteremia. However, in neutropenic febrile episodes, PCT only distinguished bacteremia from non-bacteremia. In non-neutropenic episode, both PCT and CRP showed good diagnostic accuracy (AUC: 0.757 vs. 0.763). In febrile neutropenia, only PCT discriminated bacteremia from non-bacterial infection (AUC: 0.624) whereas CRP could not detect bacteremia (AUC: 0.500, 95% CI: 0.439-0.561, P > 0.05). In this single-center observational study, PCT was more valuable than CRP for discriminating between bacteremia and non-bacteremia independent of neutropenia or HSCT.
Highlights
Infectious complications remain a major issue in patients with hematological malignancy following chemotherapy or hematopoietic stem cell transplantation (HSCT)
PCT levels were significantly higher in Gramnegative bacilli (GNB) infectious episodes than those in febrile episodes caused by fungal infection (0.58 ng/mL vs. 0.22 ng/mL (0.16–0.38), P = 0.047)
In patients with febrile episodes, leukemia (57.8%), including acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML), was the most frequent diagnosis followed by lymphoma (18.6%)
Summary
Infectious complications remain a major issue in patients with hematological malignancy following chemotherapy or hematopoietic stem cell transplantation (HSCT). CRP levels are frequently increased in non-infectious complications They show low specificity for infection, especially in patients with hematologic malignancies [5,6,7,8]. Koya et al [1] have demonstrated that PCT could provide information for discriminating between bacterial or fungal infection and other causes. It could predict patient’s prognosis after HSCT [1, 10]. Whether PCT can discriminate bacterial infection from other etiologies of fever in patients with hematologic disorder remains controversial. The objective of this study was to investigate diagnostic values of PCT and CRP in predicting systemic bacterial infection in patients with hematologic malignancies
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