Serum Perilipin 2 (PLIN2) Predicts Multiple Organ Dysfunction in Critically Ill Patients.

Berkan Kurt,Alexander Koch,Christian Trautwein,Daniel Truhn,Lukas Buendgens,Ralf Weiskirchen,Ger Koek,Jonathan F Brozat,Frank Tacke,Philipp Hohlstein,Maximilian Schulze-Hagen,Sven H Loosen,Theresa H Wirtz,Karim Hamesch,Samira Abu Jhaisha

doi:10.3390/biomedicines9091210

Berkan Kurt, Alexander Koch + Show 13 more

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https://doi.org/10.3390/biomedicines9091210

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Perilipin 2 (PLIN2) is a lipid droplet protein with various metabolic functions. However, studies investigating PLIN2 in the context of inflammation, especially in systemic and acute inflammation, are lacking. Hence, we assessed the relevance of serum PLIN2 in critically ill patients. We measured serum PLIN2 serum in 259 critically ill patients (166 with sepsis) upon admission to a medical intensive care unit (ICU) compared to 12 healthy controls. A subset of 36 patients underwent computed tomography to quantify body composition. Compared to controls, serum PLIN2 concentrations were elevated in critically ill patients at ICU admission. Interestingly, PLIN2 independently indicated multiple organ dysfunction (MOD), defined as a SOFA score > 9 points, at ICU admission, and was also able to independently predict MOD after 48 h. Moreover, serum PLIN2 levels were associated with severe respiratory failure potentially reflecting a moribund state. However, PLIN2 was neither a predictor of ICU mortality nor did it reflect metabolic dysregulation. Conclusively, the first study assessing serum PLIN2 in critical illness proved that it may assist in risk stratification because it is capable of independently indicating MOD at admission and predicting MOD 48 h after PLIN2 measurement. Further evaluation regarding the underlying mechanisms is warranted.

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Perilipin 2 (PLIN2), referred to as Adipose differentiation-related protein (ADRP)or Adipophilin, belongs to the PAT family of lipid droplet proteins, which is named after the first three proteins that were discovered in this group (Perilipin (PLIN), ADRP/PLIN2 and TIP47 (Tail-interacting protein of 47 kDa)/PLIN3)
PLIN20 s main function is the regulation of lipid metabolism as the regulation of intracellular lipid storage and lipolysis [5,7,8,9], recent evidence uncovered various additional functions
In comparison to a healthy control group consisting of 12 blood donors free from any chronic comorbidities or laboratory abnormalities, PLIN2 serum levels were markedly elevated in intensive care unit (ICU) patients (5.23 (0.48–59.5) μg/dL vs. 1.83 (1.36–2.07) μg/dL, p < 0.001; Figure 1A)

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Perilipin 2 (PLIN2), referred to as Adipose differentiation-related protein (ADRP)or Adipophilin, belongs to the PAT family of lipid droplet proteins, which is named after the first three proteins that were discovered in this group (Perilipin (PLIN), ADRP/PLIN2 and TIP47 (Tail-interacting protein of 47 kDa)/PLIN3). Perilipin 2 (PLIN2), referred to as Adipose differentiation-related protein (ADRP). PLIN20 s main function is the regulation of lipid metabolism as the regulation of intracellular lipid storage and lipolysis [5,7,8,9], recent evidence uncovered various additional functions. A growing body of studies demonstrates the complex regulation and pathophysiological connections of PLIN2 in lipid metabolism and beyond [10,11]. There has been evidence connecting PLIN2 to the development of age-related vascular disease, such as atherosclerosis [15,23,24,25,26,27]. PLIN2 is important in regulating lipid accumulation in cardiomyocytes [28]. In addition to metabolic and cardiovascular associations, PLIN2 has been described as a potential tumor marker in prevalent malignancies such as colorectal or lung carcinoma [29,30]

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