Abstract

ABSTRACT Chronic kidney disease (CKD) is a global concern and is a serious health issue that is closely associated with cardiovascular disease (CVD). Accordingly, there is a rising clinical demand for promoting the importance of the screening and diagnosis of CVD in CKD patients. The purpose of this research was to assess the effectiveness of blood microRNA-146a and vitamin D levels in CKD detection and cardiovascular complications prediction. When CKD participants, either complicated or not, were compared to the control group, plasma rates of Vascular adhesion molecule-1 (VCAM-1) and microRNA-146a were greater, while serum vitamin D values were markedly smaller. Hence, although blood miR-RNA146a quantities can be used as a reliable and particular CKD biomarker, they cannot be used to identify CVD in CKD patients since its level was not significantly different in CKD and CKD+CVD patients.

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