Abstract
Aim: Serum magnesium levels in women’s who attained menopause naturally and surgically.
 Methods: The present analytical cross sectional study was conducted on patients (out patients and in patients) in Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar, India. Group 1 (N=60): Women who had undergone hysterectomy with bilateral salphingoophorectomy at least 6 month ago. Group 2 (N=60): Women who have attained natural menopause at least 1 year ago. Serum magnesium was estimated by magnesium by Xylidyl blue colorimetric assay.
 Results: In the present study maximum number of the patients 26 (43.3%) were in the age group of 46-50 years for the post surgical menopausal group and in the natural menopausal group maximum number of the patients were in the age group of 51-55 years 23 (38.3%). Maximum numbers of patients are multiparous in both groups. Hypomagnesemia was observed in 29 (48.3%) natural menopausal group and 17 (28.3%) were postsurgical menopausal. Hypermagnesemia was observed in 1 (1.7%) postsurgical menopausal group.
 Conclusions: The prevalence of osteoporosis is very high in this part of India. Both natural and post- surgical menopausal women have lower levels of serum magnesium.
 Keywords: Osteoporosis, Serum Magnesium
Highlights
Menopause is defined as permanent cessation of menses resulting from reduced ovarian hormone secretion that occurs naturally or is induced by surgery.[1] endocrinological status early and attain menopause 3.7 years earlier than the women who attain the natural menopause
In the present study maximum number of the patients 26 (43.3%) were in the age group of 46-50 years for the post surgical menopausal group and in the natural menopausal group maximum number of the patients were in the age group of 51-55 years 23 (38.3%)
The prevalence of osteoporosis is very high in this part of India
Summary
Menopause is defined as permanent cessation of menses resulting from reduced ovarian hormone secretion that occurs naturally or is induced by surgery.[1] endocrinological status early and attain menopause 3.7 years earlier than the women who attain the natural menopause. The onset of endocrinological changes after surgical menopause is very sudden unlike natural menopause. Decreased estrogen affects the serum and urinary level of magnesium indirectly at various levels. Decreased estrogen alters the intestinal absorption, bone resorption and renal reabsorption of magnesium.[2]. Reduced ovarian hormone secretion is mainly suggested by early development of osteoporosis in women who attained premature menopause either due to natural or surgical causes.[3] All the changes take gradual course of time after natural onset of menopause
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