Abstract
BackgroundHepatitis B virus (HBV) exerts an intense impact on host lipid metabolism. Hence the aim of present study is to determine metabolic derangement that occurred in subjects suffering from hepatitis B patients.MethodsThe fasting blood samples were collected from hepatitis B patients (n = 50) attended in Taluka hospital TandoAdam, Sindh with age and gender matched controls (n = 50). Serum lipid profile and fatty acid (FA) composition were analyzed by micro-lab and gas chromatography.ResultsThe hepatitis B patients have significantly lower level (p < 0.01) of lipid profile including total cholesterol (TC), triacylglyceride (TAG), high density lipoprotein-C (HDL-C) very low density lipoprotein-cholesterol (VLDL-C), low density lipoprotein-cholesterol (LDL-C), and total lipid (TL) in comparison to controls, indicating hypolipidemia in patients. The result of total FA composition of HBV patients in comparison to controls reveal that myristic, palmitic, docosahexaenoic acids were significantly (p < 0.05) higher, while linoleic, eicosatrienoic, arachidonic, eicosapentaenoic acids were lower in HBV patients in comparison to controls. The elongase, ∆5 and ∆6-desaturase enzymes activities were found lower, while ∆9-desaturase activity was higher in hepatitis B patients as compared to controls, which indicates the impaired lipid metabolism.ConclusionThe serum saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) were increased while polyunsaturated fatty acid (PUFA) was reduced in both total and free form in hepatitis B patients due to altered activities of enzyme desaturases with impaired PUFA metabolism and non-enzymatic oxidation.
Highlights
Hepatitis B virus (HBV) exerts an intense impact on host lipid metabolism
In 2016 [3] has reported that diseases agents interfere with the lipid metabolism by altering the liver function, which results in gathering of lipid drops in the liver cells that may cause in hepatic steatosis which results in defective secretion of very low density lipoprotein (VLDL) and alteration in the beta-oxidation
The fatty acid (FA) synthesis pathways are affected by increased production of nonesterified FA, which is a major causing factor of fatty liver patients with HBV and hepatitis C virus (HCV) [4]
Summary
Hepatitis B virus (HBV) exerts an intense impact on host lipid metabolism. The World Health Organization in 2015 estimated that 240 million people have been already suffering in the chronic stage of hepatitis B virus (HBV) infection Worldwide, and 780,000 people lost their lives every year from hepatitis B [1]. The fatty acid (FA) synthesis pathways are affected by increased production of nonesterified FA, which is a major causing factor of fatty liver patients with HBV and hepatitis C virus (HCV) [4]. The liver is an essential regulating organ plays a critical role by modulating exogenous and endogenous lipid metabolism. It is involved in the generating and reprocessing of lipid metabolites including lipoproteins
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