Abstract
THE BINDING of anti-aGal human xenoantibodies (xenoAb) to aGal epitopes expressed on pig endothelial tissues leads to cell activation and complement-mediated hyperacute xenograft rejection. Although all immunocompetent individuals have xenoAb, there is scarcely any information about the occurrence of serum xenoAb in normal people and the influence of immune or metabolic condition of each group of transplantation recipients on serum levels of xenoAb. Additionally, it has been published that human immunodeficiency virus (HIV) seems unable to infect nonhuman T cells, especially nonprimate T cells, so bone marrow xenotransplantation could be a successful therapy in selected cases to restore a competent immune system. Cognate interactions between T and B cells play a critical role for an adequate synthesis of immunoglobulins. For this reason, a severe depletion of CD41 T cells might be responsible for a decrease in xenoAb and for an easier xenograft acceptance. The aim of this study was to investigate the serum concentrations of xenoAb (IgM and IgG) in several human groups: First, a group of normal population (controls) with different ages and blood groups; second, groups of patients waiting for different types of transplantation; and third, a group of HIV-infected patients.
Published Version
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