Serum levels of thyroid hormone, vitamin D, vitamin B12, folic acid, C-reactive protein, and hemoglobin in Pseudoexfoliation and primary open angle Glaucoma

Abstract

To examine levels of serum thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), vitamin D, vitamin B12 (B12), folic acid (FA), c-reactive protein (CRP), and hemoglobin in pseudoexfoliation glaucoma (XFG) and primary open angle glaucoma (POAG) patients. A hospital-based, prospective, cross-sectional study was conducted from October 2016 through June 2017 and October 2017 through January 2018. The number of patients was 33 in the control group, 29 in the XFG group and 77 in the POAG group. The mean±SD levels of TSH, fT4, fT3, vitamin D, B12, FA, CRP, and hemoglobin were 2.52±2.07 mU/l, 1.15±0.24ng/dl, 3.16±3.37pg/ml, 20.83±14.06ng/ml, 318.29±115.48pg/ml, 7.7±4.01ng/ml, 3.78±3.83mg/l, 13.36±2.08g/dl in control group respectively. The levels for the XFG patients were as follows: TSH 2.02±1.16 mU/l, fT3 3.10±0.46pg/ml, fT4 1.18±0.19ng/dl, vitamin D 20.02±19.30ng/dl, B12 302.13±142.44pg/ml, FA 9.55±3.67ng/ml, CRP 3.69±3.22mg/l, and hemoglobin 13.58±1.38g/dl. In the POAG group, serum levels of TSH, fT4, fT3, vitamin D, B12, FA, CRP, and hemoglobin were 1.88±1.13 mU/l, 1.23±0.14ng/dl, 3.16±0.43pg/ml, 15.7±12.0ng/ml, 297.71±150.66pg/ml, 9.1±4.1ng/ml, 4.16±5.12mg/l, and 14.09±1.45 respectively. Only mean vitamin D levels show a significant difference between the control group and POAG (p=0.015). POAG patients show decreased Vitamin D levels. Our study shows no significant differences in other biochemical markers between XFG, POAG and control subjects.