The research of erythropoietin level in aqueous humor of patients with glaucoma

Abstract

Objective To evaluate the difference of the level of erythropoietin (EPO) in primary open-angle glaucoma (POAG),pseudo exfoliative glaucoma (PXFG),and neovascular glaucoma (NVG).Methods One hundred glaucoma patients and 30 single cataract patients (control group) without other ocular region disease and systemic disease were enrolled in this study.In glaucoma patients,POAG was 40 patients (POAG group),PXFG was 30 patients (PXFG group),NVG was 30 patients (NVG group).The level of EPO in aqueous humor was measured by double antibody sandwich enzyme-linked immunosorbent assay.Results The level of EPO in POAG group,PXFG group,NVG group,control group was (19.1 ±5.6),(18.8 ± 6.5),(142.7 ± 20.6),(0.9 ± 0.5) U/L.The level of EPO in POAG group,PXFG group,NVG group was significantly higher than that in control group,the level of EPO in NVG group was significantly higher than that in POAG group and PXFG group (P＜ 0.01).But the level of EPO between POAG group and PXFG group had no significant difference (P ＞ 0.05).The level of EPO in PXFG group with intraocular pressure control patients was lower than that in POAG group with intraocular pressure control patients [(14.6 ± 1.4) U/L vs.(18.5 ± 6.2) U/L],the level of EPO in PXFG group with intraocular pressure nocontrol patients was higher than that in POAG group with intraocular pressure no-control patients [(28.5 ±10.7) U/L vs.(19.2 ± 6.4) U/L],there was significant difference (P ＜ 0.05).In PXFG group,the level of EPO had positive relationship with intraocular pressure (P ＜ 0.05).The level of EPO in NVG group with intraocular pressure control and no-control patients was higher than that in POAG group and PXFG group with intraocular pressure control and no-control patients,there was significant difference (P ＜ 0.05).Single factor analysis showed that intraocular pressure,type of glaucoma had correlation with the level of EPO (P ＜0.01).Multiple factors analysis showed that type of glaucoma was the main effective factor of the level of EPO (P ＜ 0.01).Conclusions The level of EPO in POAG,PXFG and NVG patients is higher than that in single cataract patients.The associativity between the level of EPO and intraocular pressure in PXFG patients is higher than that in POAG and NVG patients. Key words: Glaucoma, open-angle;  Glaucoma,neovascular;  Intraocular pressure;  Pseudo exfoliative glaucoma;  Erythropoietin