Serum levels of cTnI, NT-proBNP, CK and CK-MB in patients with hyperthyroidism heart disease and their clinical significance

Abstract

Objective To investigate the levels of serum cardiac troponin I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase (CK), and creatine kinase MB(CK-MB) in patients with hyperthyroidism heart disease (HHD) and the significance. Methods From February, 2013 to October, 2018, 74 patients with hyperthyroidism and 74 with HHD were enrolled in the hospital and set as a hyperthyroidism group and a HHD group. 74 healthy examinees were selected as a control group. The serum levels of cTnI, NT-proBNP, CK, and CK-MB and cardiac function indicators (LVEF, LVESD, and LVEDD) were observed. The serum levels of cTnI, NT-proBNP, CK, and CK-MB were compared between the patients with different HMD scores. The correlation between serum indicators and cardiac function indicators was analyzed. Results The serum levels of cTnI, NT-proBNP, CK, and CK-MB were (0.59±0.13) µg/L,(1 765.28±153.69) pg/Ml, (316.25±54.89) U/L, and (67.42±9.76) U/L in the HHD group, were (0.30±0.08) µg/L, (549.85±72.13) pg/ml, (199.41±23.45) U/L, and (22.36±4.08) U/L in the hyperthyroidism group, and were (0.12±0.04) µg/L, (53.67±8.04) pg/ml, (42.16±7.38) U/L, and (6.51±1.13) U/L in the control group. The serum levels of cTnI, NT-proBNP, CK, and CK-MB in the HHD group> those in the hyperthyroidism group> those in the control group (all P Ⅲ>Ⅱ>I, with statistical differences (all P those in the hyperthyroidism group > those in the control group (all P<0.05). Pearson correlation analysis showed that cTnI, NT-proBNP, CK, and CK-MB negatively correlated LVEF (P<0.05), and positively with LVESD and LVEDD (all P<0.05). Conclusion Serum cTnI, NT-proBNP, CK, and CK-MB have relatively high expressions in HHD patients, which may reflect the degree of cardiac function impairment and have important auxiliary value for the clinical diagnosis and disease assessment of HHD. Key words: Hyperthyroidism heart disease; Cardiac troponin I; N-terminal pro-brain natriuretic peptide; Creatine kinase; Creatine kinase MB