Changes and clinical significance of related test indexes in patients with rheumatic heart disease

Abstract

Objective To study the clinical changes and significance of laboratory index in rheumatic heart disease (RHD) patients. Methods Sixty-eight RHD patients treated from January 2016 to September 2018 in Henan Thoracic Hospital were selected as the observation group, and 70 healthy check-ups were selected as the control group. The vein blood was drawn to detect the laboratory index, including erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), creatine kinase MB isoenzyme (CK-MB), cardiac troponin I (cTnI) and myohemoglobin (Mb) concentrations. Results The values of ESR, RF, CRP, CK-MB, NT-proBNP, Mb and cTnI in the observation group were significantly higher than those in control group (P<0.05). The positive diagnosis rate of NT-proBNP, Mb, CTnI and CK-MB in the observation group was significantly higher than those in the control group (P<0.05). The diagnosis sensitivity and specificity based on the combined examinations of NT-proBNP, Mb, CTnI and CK-MB were significantly higher than those of the single examination (P<0.05). The NT-proBNP values were positively correlated with the cTnI and Mb concentrations. Conclusions Laboratory indexes are closely related to rheumatic heart disease, especially NT-proBNP, cTnⅠ and Mb, which can be used to predict rheumatic heart disease and to diagnose and treat rheumatic heart disease. Key words: Rheumatic heart disease; Laboratory index; Myocardial injury markers