Serum levels of C1q/TNF-related protein-1 (CTRP-1) are closely associated with coronary artery disease.

Huizhong Wang,Fangliang Li,Yuntian Li,Ru Wang,Dayong Du

doi:10.1186/s12872-016-0266-7

Huizhong Wang, Fangliang Li + Show 3 more

Open Access

https://doi.org/10.1186/s12872-016-0266-7

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Abstract

BackgroundComplement C1q tumor necrosis factor related proteins (CTRPs) have been proved to have diverse biological influences on cardiovascular system. CTRP 1 is a member of the CTRP superfamily, however, the relevance with coronary artery disease (CAD) are seldom explored. This study was designed to investigate the correlation between serum levels of CTRP 1 and CAD.MethodsCTRP 1 levels of 150 CAD patients and 50 non-CAD subjects were determined by enzymelinked immunosorbent assay. Further analysis of CTRP 1 levels in different stages and lesion vessels of CAD were conducted.ResultsSerum levels of CTRP 1 in CAD patients were significantly elevated, and it was increased with the severity of CAD. CTRP 1 level in acute myocardial infarction group was much higher than that in stable/unstable angina and non-CAD groups. And significant differences of CTRP 1 were also found between single-vessel disease and triple-vessel disease. Multiple logistic regression analysis showed that CTRP 1 was an independent risk factor of the occurrence of myocardial infarction.ConclusionsIncreased serum CTRP 1 levels were closely associated with the prevalence and severity of CAD, it might be regarded as a marker for myocardial infarction.

Highlights

Complement C1q tumor necrosis factor related proteins (CTRPs) have been proved to have diverse biological influences on cardiovascular system
Stable and unstable angina pectoris were determined by American College of Cardiology (ACC)/American Heart Association (AHA) 2007 guidelines [12], the diagnosis of acute myocardial infarction was performed according to the clinical history, electrocardiogram and serum myocardial enzymogram
High density lipoprotein-cholesterol (HDL-c) level was lower in coronary artery disease (CAD) group than that in non-CAD group

Summary

Introduction

Complement C1q tumor necrosis factor related proteins (CTRPs) have been proved to have diverse biological influences on cardiovascular system. CTRP 1 is a member of the CTRP superfamily, the relevance with coronary artery disease (CAD) are seldom explored. This study was designed to investigate the correlation between serum levels of CTRP 1 and CAD. Complement C1q tumor necrosis factor related proteins (CTRPs) superfamily is a cluster of adipokines, currently, 15 members are identified [1]. The members of CTRPs participate in the regulation of physiological and pathological processes, such as glucose and lipid metabolism, inflammation, myocardial protection, vasodilatation. Coronary artery disease (CAD) is one of the most prevalent cardiovascular diseases, it is a group of diseases that included: stable angina, unstable angina, myocardial infarction, and sudden coronary death [8]. In 2013, CAD was the most common cause of death

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