Abstract
Wilms’ tumour (WT) and soft tissue sarcomas (SA) in children lack reliable biochemical markers. This study was carried out to determine the clinical significance of serum soluble interleukin-2 receptor α (sIL-2Rα) in the diagnostics and treatment monitoring of children with WT and SA. The study included 48 children: ten with WT, eight with SA and 30 healthy controls. The sIL-2Rα levels (ELISA) and rates of elevated sIL-2Rα values were estimated prospectively at diagnosis and in complete remission during treatment and after therapy. As the dependence on age was determined, the levels of sIL-2Rα were expressed as multiplications of the upper value of the normal range for a particular age (xN). Median pretreatment levels of sIL-2Rα in patients exceeded those of healthy controls (1.79 xN for WT and 1.53 for SA vs. 0.61 for controls; p<0.001) as did the rates of elevated sIL-2Rα values (80% of WT and 87.5% of SA patients vs. 0% of controls). Good response to therapy was paralleled by a significant decline of pretreatment sIL-2Rα levels and its elevated rates. Thus, sIL-2Rα determination may be of some value in the diagnostics and treatment monitoring of childhood WT and SA.
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