SERUM LEVEL OF ADVANCED OXIDATION PROTEIN PRODUCTS AND THE ACTIVITY OF SUPEROXIDE DISMUTASE AS THE MARKERS OF OXIDATIVE STRESS IN PATIENTS WITH CHRONIC HEART FAILURE

Abstract

Aim.The present work was aimed at studying and analysing the serum level of advanced oxidation protein products (AOPPs) and the total superoxide dismutase activity (total SOD) in patients with chronic heart failure (CHF) with a preserved and low left ventricular ejection fraction, depending on the stage of the disease.Materials and methods.Patients with CHF (n=280) were divided into groups depending on the left ventricular ejection fraction (patients with a preserved and low left ventricular ejection fraction) and the stage of the disease (I–III). The control group consisted of somatically healthy individuals (n=60). The level of the activity of all three types of SOD (Cu/Zn-SOD+MnSOD+Fe-SOD) and the level of AOPPs were analysed in the serum by enzyme immunoassay.Results.All CHF patients as compared to somatically healthy individuals showed an increase in the level of AOPPs and a decrease in the activity of total SOD, being more pronounced in patients with a low left ventricular ejection fraction. In the subgroups of patients with a more severe CHF stage, a statistically significant increase in the level of AOPPs and a decrease in the activity of total SOD as compared with subgroups with a less severe CHF were observed. Patients with a low ejection fraction of the left ventricle of I, IIA and IIB+III stages experienced higher levels of AOPPs and lower levels of total SOD than patients with a preserved left ventricular ejection fraction of the corresponding stages of the disease. A correlation analysis revealed the presence of statistically significant correlations of medium strength in patients with CHF with a preserved and low left ventricular ejection fraction with the clinical manifestations of CHF.Conclusion.The dynamics of the total SOD and AOPP levels, depending on the left ventricular ejection fraction and the stage of the disease, indicates the association of the CHF severity with that of oxidative stress. Conflict of interest: the author declares no conflict of interest.