Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression.

Jiang Xue,Chao Sun,Yanfeng Xiao,Min Si,Wei Wang,Shuang Liang,Wei Song,Kailin Li,Maria L Dufau

doi:10.1155/2020/3126309

Abstract

Aim The aim of this study was to evaluate the levels of kisspeptin and AMH in children with PT or CPP or controls to provide a reference for diagnosis and prognosis. Methods 38 Chinese children with central precocious puberty (CPP), 38 Chinese children with premature thelarche (PT), and 75 controls were recruited. Results In CPP girls, AMH levels decreased significantly compared to control girls at T2 stage. Compared with the PT and control groups, AMH is the lowest in girls in the CPP group at T3 stage. Kisspeptin decreased significantly in girls in the PT group and increased significantly in girls in the control group from T2 stage to T3 stage. At T3 stage, kisspeptin was significantly higher in girls in the CPP and control groups than in the PT group. In the control group, kisspeptin was significantly higher in boys than in girls at T2 stage. AMH and height were negatively correlated in the girls group. Conclusions Kisspeptin and AMH have a unique significance in the auxiliary diagnosis, the differential diagnosis, the treatment, and prognosis of sexual puberty disorder.

Highlights

Precocious puberty is traditionally defined as the onset of pubertal development before the age of eight years in girls and nine years in boys, or menstruation starts before ten years in girls in China [1]
Kisspeptin and anti-Müllerian hormone (AMH) have a unique significance in the auxiliary diagnosis, the differential diagnosis, the treatment, and prognosis of sexual puberty disorder
It was found in our clinical treatment that some patients of premature thelarche (PT) developed central precocious puberty (CPP), which needs diagnosis and treatment in the early stages. e cause and auxiliary diagnosis of CPP is a focus of current research in the field [3]

Summary

Introduction

Precocious puberty is traditionally defined as the onset of pubertal development before the age of eight years in girls and nine years in boys, or menstruation starts before ten years in girls in China [1]. AMH has the function of regulating sex hormone production, and its level changes have been related to the onset of puberty in both sexes [8], as the different physiological structure of the gender, time, and amount of AMH secretion are different. It is not clear how AMH participates in precocious puberty. E aim of this study was to evaluate the change of kisspeptin and AMH in children with PT or CPP or controls to provide a reference for diagnosis, treatment, and prognosis. Statistical significance was defined as P < 0.05 for all variables

Results

Conclusions

Ethical Approval