Abstract
The aim of this study was to measure serum leptin and vitamin D levels in remission in Behcet's disease (BD) and to investigate the relationship between leptin and vitamin D levels with neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR). This study was conducted in 20 healthy volunteers and 27 BH who were in remission. The age, sex, and body mass index values (BMI) of both groups were recorded. Venous blood samples were taken from both groups at the end of 12 h fasting. Serum leptin, vit-D, high-sensitivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC), neutrophil, lymphocyte and platelet counts were measured from the obtained sera according to the kit protocols. There was no statistically significant difference between the groups in terms of hsCRP, ESR, WBC, leptin, vit-D and NLR and PLR values (p> 0.05). Correlation of leptin levels with NLR and PLR values in both groups were not statistically significant (p>0.05). The results showed that there was no relationship between the measured values and the course of the diseaseBD
Highlights
Behcet's disease (BD) is a chronic, recurrent, inflammatory disease that mainly involves mucocutaneous, ocular, joint, vascular and central nervous system involvement as well as other systems [1, 2]
When chronic inflammation is thought to play a role in BD, neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) are suggested to be used for acute and remission follow-up [3,4] T helper (Th) 1 response and proinflammatory cytokines such as interleukins (IL) (IL 6, IL 8, IL 17, IL 18) and tumor necrosis factor (TNF) -α are involved in the activation of T cells and neutrophils [5]
Fifty patients with BD and 20 healthy volunteers were included in the study
Summary
Behcet's disease (BD) is a chronic, recurrent, inflammatory disease that mainly involves mucocutaneous, ocular, joint, vascular and central nervous system involvement as well as other systems [1, 2]. Activation of T cells and neutrophils plays an important role in the pathogenesis of the disease. When chronic inflammation is thought to play a role in BD, NLR and PLR are suggested to be used for acute and remission follow-up [3,4] T helper (Th) 1 response and proinflammatory cytokines such as interleukins (IL) (IL 6, IL 8, IL 17, IL 18) and tumor necrosis factor (TNF) -α are involved in the activation of T cells and neutrophils [5]. Leptin occupies a role in the initiation of the Th1 response, while vitamin D, the immunomodulator, has the suppressive effect of the Th1 response [8, 9]. In the recent researchs the effect of vitamin D on disease in BD, the results are contradictory [12]
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