Serum IgE in clinical immunology and allergy

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Serum IgE was measured with the use of the Rowe modification of the Mancini technique. Serum IgE was significantly elevated in atopic and questionably atopic patients and in patients with filariasis within 2 years of diagnosis. Children with thymic hypoplasia and with cystic fibrosis had higher IgE levels than did control clinic patients. Children with variable immunodeficiency and X-linked agammaglobulinemia had significantly less IgE than did control patients, and patients with severe combined immune deficiency disease when not treated with plasma had no detectable IgE. The value of IgE determinations in groups of patients was demonstrated.