Serum high-density lipoprotein correlates with serum apolipoprotein M and A5 in obstructive sleep apnea hypopnea syndrome

Shengyu Tan,Yan Xu,Yawen Gao,Shenghua Zhou,Xianling Liu,Lu Luo

doi:10.1007/s11325-016-1357-5

Abstract

PurposeThe purpose of this study was to investigate the correlation between serum levels of serum apolipoprotein M (ApoM), A5 (ApoA5), and high-density lipoprotein (HDL) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and study the effects of nasal continuous positive airway pressure treatment on these serum biomarkers.MethodsThirty OSAHS patients and 15 non-OSAHS probands as control were selected for the study. Serum HDL, ApoM, and ApoA5 levels in two groups were detected; differences and association among them were analyzed. Patients with moderate and severe OSAHS underwent 3-month auto-continuous positive airway pressure treatment, and a comparative study was conducted to investigate the changes in blood lipids, serum ApoM, and ApoA5.ResultsIn comparison to the control group, the HDL, ApoM, and ApoA5 serum levels were lower (P < 0.05). HDL was positively correlated to ApoM and ApoA5 (P < 0.001), and ApoM was positively correlated to ApoA5 (r = 0.536, P < 0.001). HDL, ApoM, and ApoA5 were significantly increased in the patients of moderate and severe OSAHS after auto-continuous positive airway pressure treatment for 3 months (P < 0.05).ConclusionsThe HDL level was significantly lower in OSAHS patients. The decrease in serum ApoM and ApoA5 in OSAHS patients was correlated to the severity of OSAHS and HDL levels. Auto-continuous positive airway pressure treatment increased serum levels of ApoM, ApoA5, and HDL in OSAHS patients.

Highlights

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a disorder with a high incidence and potential risks, manifested as snoring accompanied with respiratory pauses, hypopnea, shallow breathing, recurrent hypoxemia, and hypercapnia acidosis during the night [1,2,3]
Purpose The purpose of this study was to investigate the correlation between serum levels of serum apolipoprotein M (ApoM), A5 (ApoA5), and high-density lipoprotein (HDL) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and study the effects of nasal continuous positive airway pressure treatment on these serum biomarkers
Serum levels of HDL, ApoM, and ApoA5 were lower in the OSAHS group, and the mean nocturnal SaO2 and minimum SaO2 were significantly lower in the OSAHS group in comparison to the controls

Summary

Introduction

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a disorder with a high incidence and potential risks, manifested as snoring accompanied with respiratory pauses, hypopnea, shallow breathing, recurrent hypoxemia, and hypercapnia acidosis during the night [1,2,3]. It has been shown that the blood lipid profile of OSAHS patients is abnormal, manifesting as a significant increase in triglyceride (TG), total cholesterol (CHOL), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), apolipoprotein B (ApoB), and lipoprotein a (Lpa) in serum, while high-density lipoprotein (HDL) and apolipoprotein A (ApoA) levels decrease. This abnormal blood lipid profile might be a causative factor of cardiovascular disease [12,13,14]

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