Abstract
Fifteen Sahel goats were randomly allocated into three groups A, B and C to evaluate Serum Haptoglobin (Hp) profiles following rumenotomy as markers of surgical stress using Quantitative ELISA. Diazepam at 0.2mg/kg was administered intravenously to sedate goats in groups A and B with subsequent lidocaine HCl and bupivacaine inverted-L block for groups A and B respectively. Group C did not receive any treatment. Chromic catgut (CCG) and Polyglycolic Acid (PGA) sutures were used for rumen closure and apposition of abdominal muscles for groups A and B respectively while nylon for skin closure. Blood samples were collected via jugular venipuncture before induction of anaesthesia to establish baseline data. Further blood sampling were at five minutes post anaesthetic induction (PAI) and immediately after surgery 0 hour (38±6.0 minutes post surgery), then subsequently at 5, 8, 24, 48 and 72 hours post surgery. Values in groups A and B differs significantly (P<0.05). Group A peak Hp values was 6.23±1.82 mg/mL at 72hrs post surgery. The goats in group B had a peak of 4.26±1.55 mg/mL Hp at 72hrs post surgery. Hp in the Sahel goat showed no significant stress at five minutes post induction of local anaesthesia with lidocaine and bupivacaine post diazepam sedation. The sutures in the experiment CCG and PGA, produced significant stress but was earlier in onset and highest in concentration among goats that had sutured rumen and abdominal muscles with CCG (group A).
Highlights
Rumenotomy a surgical incision into the rumen is a routine surgical procedure that is performed to relieve some disease conditions of the rumen and/or fore stomach
Chromic catgut (CCG) and Polyglycolic Acid (PGA) sutures were used for rumen closure and apposition of abdominal muscles for groups A and B respectively while nylon for skin closure
This study provides serum Hp profile of Sahel goats at five minutes post anesthetic induction of local anesthesia with lidocaine and bupivacaine after diazepam sedation
Summary
Rumenotomy a surgical incision into the rumen is a routine surgical procedure that is performed to relieve some disease conditions of the rumen and/or fore stomach. Some studies reported that silk elicits more intense tissue inflammatory response and delayed wound healing as compared to other suture materials including polyglecaprone-25, polyglycolic acid (PGA), and nylon [5]. Several studies reported that tissue reactions are minimal with nylon sutures and this was why nylon was chosen in this study for both experimental groups to evaluate a clearer effect or response of the absorbable sutures [5] These serious changes in the response to surgical sutures after being buried in the wound bed is yet to be captured on acute phase protein profiling such as Hp, notably looking into how chromic catgut and polyglycolic acid sutures are frequently used in the study area. Diazepam at a dose rate of 0.1- 0.25 mg/kg is used in goats for sedation administered as slow intravenously injection to
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