Abstract
The relationships between spermatogenesis and gonadotropic and androgenic hormones were studied by measuring levels of serum FSH, LH and testosterone in rats during loss and recovery of spermatogenic elements. Male rats weighing 250–350 g were treated with a single ip dose of the antispermatogenic agents busulfan (1,4-dimethanesulf onoxybutane; 10 mg/kg) or WIN 1S446 (bis(dichloroacetyl)-octamethylenediamine; 125 mg/kg) or with vehicle alone. Groups of control, busulfan- and WIN 18446- treated rats were sacrificed periodically between 1 and 20 weeks after treatment. Testis weights of treated rats decreased rapidly during 3-6 weeks after treatment, reaching minimal (p < 0.01) levels (0.64 g for busulfan, 0.68 g for WIN 18446, 1.51 g for controls) by 8 weeks after treatment. Thereafter, testis weight increased, but remained below (p < 0.05) control levels 20 weeks after treatment. Histological loss of spermatogenic elements, paralleling weight loss was seen; by 8 weeks after treatment, seminiferous tubules ...
Published Version
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