Abstract
In 1968 <sup>Shaw et al.</sup><sup>11</sup>reported that both "frank" diabetics with abnormal and "early" diabetics with unimpaired glucose tolerance showed a greater than normal rise in total serum fucose, determined by a modified technique, after oral glucose. We report similar studies in which the serum fucose concentration was determined both by their method and by the more specific technique of Winzler.<sup>15</sup> The results indicate that the increase in serum fucose detected by <sup>Shaw et al.</sup><sup>11</sup>is only apparent being due, in major part, to the participation of blood glucose in their method of fucose determination, and fail to confirm their view that the "combined glucose-fucose response provides an objective biochemical test for the detection of diabetes mellitus prior to the onset of hyperglycemia."
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