Abstract
In 1968 Shaw et al. 11 reported that both “frank” diabetics with abnormal and “early” diabetics with unimpaired glucose tolerance showed a greater than normal rise in total serum fucose, determined by a modified technique, after oral glucose. We report similar studies in which the serum fucose concentration was determined both by their method and by the more specific technique of Winzler. 15 The results indicate that the increase in serum fucose detected by Shaw et al. 11 is only apparent being due, in major part, to the participation of blood glucose in their method of fucose determination, and fail to confirm their view that the “combined glucose-fucose response provides an objective biochemical test for the detection of diabetes mellitus prior to the onset of hyperglycemia.”
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