Serum fatty acid transport protein 1 in women with and without breast cancer

Abstract

Introduction and Aim: Obesity influences the serum lipid profiles leading to dysregulation of lipid metabolism in which fatty acid transporter like FATP 1 (Fatty acid transport protein 1) are recognized to play a key role in BC progression. Aim of the present study is to compare FATP1 levels in women with and without BC. Materials and Methods: In this case-control study, 50 BC and 50 control subjects were recruited. Serum was separated from the blood and baseline characteristics like height, weight, age and BMI were noted for all the subjects. Lipid profile and serum level of FATP1 was estimated using a commercially available kit. P<0.05 was found as statistically significant. Results: The serum FATP1 levels in subjects with breast cancer differed significantly between the case and control. TC, TAG, HDL-C, LDL-C, and VLDL-C differed between two groups and were statistically significant. Further, serum FATP1 levels in subjects with BC were compared based on the status of the receptor showed a significant difference in TG, VLDL-C and serum FATP1.Correlating the serum FATP1 levels with baseline characteristics and lipid profiles in subjects with BC, age showed a positive correlation with serum FATP1 levels. Correlation of FATP1 with different receptor status in subjects with BC showed a positive correlation between FATP1 and VLDL in ER+/PR-/HER2+ receptor status, FATP1 and HDL-C showed a positive correlation in triple-negative BC. Conclusion: Though extensive research on breast cancer is underway, Study reports on serum level of FATP1 in BC are scarce. Current study demonstrates the importance of serum levels of FATP1 in BC. Further study on the molecular regulation of FATP1 in BC will add to the knowledge, and findings of the study implicates for utilizing FATP1 as a biomarker in BC.