Serum Fas levels during first week of sepsis are associated with severity and mortality

Abstract

ABSTRACT Introduction The aim of our study was to explore whether there is an association of serum sFas (cell death apoptosis receptor) concentrations during the first week of sepsis with sepsis severity and sepsis mortality. Methods In this observational study, septic patients were recruited. Serum sFas concentrations were determined on days 1, 4, and 8 of sepsis diagnosis. Thirty-day mortality was the outcome variable. Results Surviving patients (n = 181) compared to non-survivors (n = 101) presented lower serum sFas levels on day 1 (p < 0.001), day 4 (p < 0.001) and day 8 (p < 0.001), and lower SOFA on day 1 (p < 0.001), day 4 (p < 0.001) and day 8 (p < 0.001). Logistic regression analyses showed associations between 30-day mortality and serum sFas levels controlling for SOFA on day 1 (OR = 1.005; 95% CI = 1.003–1.007; p < 0.001), day 4 (OR = 1.044; 95% CI = 1.029–1.060; p < 0.001) and day 8 (OR = 1.012; 95% CI = 1.002–1.022; p = 0.02). Conclusions The association of serum sFas concentrations during the first week of sepsis with sepsis severity and sepsis mortality were our new findings.