Abstract
Large cerebral artery stenosis is a major cause of acute ischemic stroke (AIS); however, the correlation between serum cystatin C (CysC) and the stenosis of large cerebral arteries in patients with AIS has not been established. We performed a retrospective review of acute ischemic stroke patients, who were examined by cerebral digital subtraction angiography(DSA). Participants (252 cases) included 131 patients without stenosis and 121 patients with large cerebral artery stenosis. Serum CysC levels in patients with large cerebral artery stenosis were much higher than that of control subjects (p<0.001). However, serum CysC levels were not related to the location of stenosis. Further, logistic regression analyses showed that increased serum CysC was an independent risk factor of large cerebral artery stenosis in patients with acute ischemic stroke. Total participants were subdivided into quintiles based on serum CysC levels. Compared with the first quintile, the odds ratios of risk for large cerebral artery stenosis in the fourth and the fifth quintile were 1.26 (p<0.05) and 4.71(p<0.05) respectively, after the adjustment for age, sex, and smoking, hypertension, type 2 diabetes mellitus(DM), dyslipidemia, creatinine(Cr), urea, uric acid, and C reactive protein(CRP). Therefore, a significant positive correlation was observed between elevated serum CysC levels and large cerebral artery stenosis in patients with acute ischemic stroke. In summary, our findings provide new insights into the correlation between increased serum CysC and large cerebral artery stenosis in patients with acute ischemic stroke.
Highlights
Acute ischemic stroke contributes substantially to the global burden of disease and disability with the aging of the population [1, 2]
We performed a retrospective review of acute ischemic stroke patients, who were examined by cerebral digital subtraction angiography(DSA)
To examine the relationship between increased serum cystatin C (CysC) and large cerebral artery stenosis, regression analyses were performed in patients with acute ischemic stroke (AIS)
Summary
Acute ischemic stroke contributes substantially to the global burden of disease and disability with the aging of the population [1, 2]. The cost of stroke and Stroke cytoprotection were high, with a global stroke incidence of 10.3–16.9 million annually and a high risk for recurrence in patients who suffer an acute stroke [3, 4]. Large-artery atherosclerosis subtype is one of the main types of acute ischemic stroke. Hypertension, hyperlipidemia and diabetes are involved in the development of atherosclerosis,which plays an important role in the process of large cerebral artery stenosis. Patients with well-controlled these factors still have a high incidence of cardiovascular events [6,7,8]. Finding the risk factors of large cerebral artery stenosis is a topic of considerable interest
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