Changes of plasma NGAL and serum CysC in patients with essential hypertension and its clinical significance

Abstract

Objective To explore the levels of neutrophil gelatinase-associated lipocalin(NGAL)and Serum cystatin C(CysC) in plasma in essential hypertension(EH) and to discuss their clinical significance. Methods 92 patients with essential hypertension were selected as EH group. At the same time, 88 healthy subjects were selected as the healthy control group. The levels of plasma NGAL, serum CysC and some other biochemical markers were detected. The results were statistically processed. Results The level of Plasma NGAL in EH group was(149.22±11.52)μg／L and the level of serum CysC in EH group was(0.92±0.03)mmol／L. The level of Plasma NGAL in the healthy control group was(101.4±7.71)μg／L and the level of serum CysC in the healthy control group was(0.71±0.02)mmol／L. The levels of Plasma NGAL and serum CysC were significantly increased in EH group compared with those of the healthy control group(F＝27.491,P＜0.01;F＝24.646,P＜0.01). Plasma NGAL was positively corre-lated with the degree of EH and the level of serum CysC(r＝0.48,P＜0.01). Conclusion Plasma NGAL and serum CysC were significantly increased in EH patients, with a significant positive correlation to the degree of nephropathy damage. Both of them can become diagnostic measurements for early diagnosis of nephropathy damage induced by EH. Key words: Hypertension; Granulocytes; Gelatinases; Membrane transport proteins; CysC