Abstract
Background: Longitudinal studies assessing the association between copper and the risk of CVD mortality among aging populations without diabetes are scarce. We sought to examine the prospective association between serum copper and future risk of CVD mortality among a general population sample of men without diabetes in Finland. Method: We used the population-based data from the Kuopio Ischaemic Heart Disease Study, comprising men aged 42-60years at baseline. Serum copper concentrations were determined using Atomic Absorption Spectrometer and categorized into quartiles. The associations with CVD mortality were analyzed using multivariable Cox regression models. Results: After a median follow-up period of 26years, 524 CVD deaths occurred among 2,395 men. After adjustment for age, BMI, blood pressure, history of coronary heart disease(CHD), high-density cholesterol, total cholesterol, smoking, alcohol and socioeconomic status, the hazard ratios (and 95% CIs) for CVD mortality for serum copper concentrations in the second, third and fourth quartiles were 1.03(0.78-1.36), 1.32(1.04-1.68) and 1.50(1.18-1.91) respectively (using the first quartile as the referent). The association remained consistent following the exclusion of men with a history of CHD. Conclusions: This study reveals that elevated serum copper concentrations at baseline are associated with future risk of CVD mortality. Thus, prompting the possible role of serum copper levels as a biomarker for CVD mortality in men without diabetes. The role of serum copper as a putative risk factor for CVDs requires further exploration. The exact mechanisms underlying the association between elevated serum copper concentration and the risk of CVD mortality are yet to be unraveled.
Published Version
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