SERUM CHEMERIN LEVEL IN RELATION TO RENAL FUNCTION IN EXPERIMENTALLY INDUCED DIABETIC RATS

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Background: Chemerin, a recently discovered adipocytokine, regulates adipocyte development and metabolism as well as inflammatory and immune function. Data onto chemerin levels in diabetes and its associated renal affection is limited and controversial. Objective: This work was designed to evaluate the serum chemerin level in acute and chronic experimentally-induced diabetes and its relation to some metabolic parameters, and renal function tests. Materials and Methods: This study was done on 30 adult healthy male of local strain albino rats. Animals were divided into three equal groups, i.e.healthy group, acute diabetic group and chronic diabetic untreated group. Diabetes was induced experimentally by intra peritoneal injection of streptozotocin (STZ). In each of the three groups, each animal was put inside a cage to collect 24h urine tomeasure albuminuria, then they were sacrificed, and sera were examined for levels of glucose, insulin, chemerin , cholesterol, triglycerides (TG), high density lipoproteins (HDL) , Low density lipoproteins (LDL), urea, creatinine, creatinine clearance, C-reactive protein (CRP), and tumor-necrosing factor alpha (TNF-α). Results: There was a significant increase in serum chemerin levels in the chronic diabetic untreated group when compared to both control and acute diabetic groups. Also, there were significant positive correlations between serum chemerin levels and serum urea, creatinine, urine albumin, serum cholesterol, TG, LDL, CRP and TNF-α levels, as well as negative correlations between serum chemerin levels, and both serum creatinine clearance and HDL levels in the chronic diabetic untreated group. Conclusion: Serum chemerin levels seemed to be related to impaired renal function test (albuminuria, serum creatinine, urea and creatinine clearance) rather than to serum insulin level. Serum chemerin levels elevated, without any concomitantsignificant change in serum insulin in chronic diabetic group, when compared to acute diabetic group. Accordingly, it can be hypothesized that the change of serum chemerin could be considered as a predicting marker of diabetic nephropathy rather than of diabetes.