Abstract
CD44 is a cell surface adhesion molecule demonstrated to be a receptor for hyaluronate (HA). Since serum HA is known to increase in patients with liver cirrhosis (LC), we investigated whether serum CD44 levels are increased in patients with chronic liver diseases. Serum CD44 concentration in patients with LC was significantly ( P < 0.05) higher than that in patients with chronic hepatitis (CH). Patients with CH had also significantly more elevated levels of serum CD44 than normal controls ( P < 0.01). However, no significant difference was observed in serum CD44 levels among chronic persistent hepatitis, chronic aggressive hepatitis with moderate activity (CAH 2A) and chronic aggressive hepatitis with severe activity (CAH 2B). Similar results were obtained for serum HA. Serum CD44 levels also showed significant ( P < 0.01) correlation between serum HA in patients with CH and LC. These results indicate that serum CD44 as well as HA is increased in patients with chronic liver diseases, especially with LC.
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