Abstract
BackgroundThough increasing epidemiological studies have evaluated the correlation between serum calcium contents and Parkinson’s disease (PD), the results are inconsistent. At present, whether there is a causal association between serum calcium content and PD remains undetermined.Objective and MethodsThis study was designed to explore the relationship between increased serum calcium contents and PD risk. In this present study, a Mendelian randomization trial was carried out using a large-scale serum calcium genome-wide association study (GWAS) dataset (N = 61,079, Europeans) and a large-scale PD GWAS dataset (N = 8,477, Europeans including 4,238 PD patients and 4,239 controls). Here, a total of four Mendelian randomization methods comprising weighted median, inverse-variance weighted meta-analysis (IVW), MR-Egger, and MR-PRESSO were used.ResultsOur data concluded that genetically higher serum calcium contents were not significantly related to PD.ConclusionIn conclusion, we provided genetic evidence that there was no direct causal relationship between serum calcium contents and PD. Hence, calcium supplementation may not result in reduced PD risk.
Highlights
Previous studies indicated that calcium is involved in many biological processes, and altered calcium homeostasis is widely regarded as a basis for cognitive deficits in normal subjects and certain neurodegenerative diseases (LaFerla, 2002; Larsson et al, 2017)
The bone density and mineral metabolism in 82 Parkinson’s disease (PD) patients and 68 age- and sexmatched controls were measured, of which the results showed that serum calcium and vitamin D levels were significantly decreased in PD patients compared with controls
From the discovery and validation PD genome-wide association study (GWAS) datasets, eight genetic variants associated with serum calcium levels were extracted for statistical analysis
Summary
Previous studies indicated that calcium is involved in many biological processes, and altered calcium homeostasis is widely regarded as a basis for cognitive deficits in normal subjects and certain neurodegenerative diseases (LaFerla, 2002; Larsson et al, 2017). Emerging epidemiological research has evaluated the correlation between serum calcium contents and PD, and calcium dysregulation has been found in PD (Abou-Raya et al, 2009; Meamar et al, 2013; Schapira, 2013; Liu J. et al, 2016). The results reported by these studies are often inconsistent. Though increasing epidemiological studies have evaluated the correlation between serum calcium contents and Parkinson’s disease (PD), the results are inconsistent. Whether there is a causal association between serum calcium content and PD remains undetermined
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