Abstract
Twenty-nine women were treated with biphasic combined oral contraceptive pills containg ethinyl estradiol 0.05 mg and levonorgestrel 0.050–0.125 mg. Serum primary bile acids (cholic acid and chenodeoxycholic acid) and one secondary bile acid (deoxycholic acid) were measured by radioimmunoassay. The serum samples were collected before the treatment and at one, three and twelve months during the treatment. No significant changes were found in these bile acid levels during the treatment. The ratio of cholic/chenodeoxycholic acid did not change either. No pathological values were found in the conventional liver function tests although serum alanine aminotransferase activity was significantly increased after twelve months treatment. It can therefore be concluded that the present contraceptive pill not cause a any liver dysfunction detectable by bile acid measurement on other “classical” liver function tests.
Published Version
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