Serum BDNF changes before and after treatment and the relative factors in depressive patients

Yumei Zhang ,Xiaobin Zhang ,Wei Sha ,Zhijun Zhang ,Honghui Zhou

doi:10.3760/cma.j.issn.1006-7884.2009.04.008

Yumei Zhang , Xiaobin Zhang + Show 3 more

https://doi.org/10.3760/cma.j.issn.1006-7884.2009.04.008

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Objective To explore the correlations between serum levels of brain-derived neurotrophic factor(BDNF)and negative life events,pathophysiology of depression and therapeutic effect in depressive Datients before and after antidepressant treatment.Methods The serum BDNF levels in depressive patients(n=63)before and after 2,4,and 8 week antidepressant treatment and normal control subiects(n=80)were assayed with the ELISA method.And the subjects were assessed with the Hamilton Depression Scale(HAMD)and Life Event Scale.Results The serum BDNF levels in depressive patients at baseline[(24±14)μg/L]were significantly lower than that in controls[(36±15)μg/L J(t=-4.863,P=0.000).and were significantly negatively correlated with scores of the negative lire events and HAMD scores(r=-0.331.-0.343,P=0.008,0.006).The serum BDNF levels in depressive patients after 2 week treatment were still significantly lower than that in controls(t=-5.990,P=0.000),and were negatively correlated with the severity of depression(r=-0.269,P=0.033),and the rate of increase in the serum BDNF levels was positively correlated with the rate of decline in their HAMD scores(r=0.252,P=0.047).The serum BDNF levels in depressive patients after 4 and 8 week treatment were higher than that before treatment(by LSD test.P=0.000;P=0.005),and no longer differed from that in controls (both P＞0.05).There were a gradual decrease in HAMD scores(all were lower than that at baseline,all P=0.001)and a gradual increase of rate of decline in their HAMD scores(respectively 40%,66%and 74%)in depressive patients after 2,4 and 8 week treatment.Conclusions Low serum BDNF levels in depressive patients are possibly correlated with negative life events and pathophysiology of depression.Increase of serum BDNF levels in depressive patients may be a pivotal marker of antidepressant therapeutic effect. Key words: Depressive disorder; Brain-derived neurotrophic factor; Life change events; Antidepressive agents:Electroshock

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