Serum Apolipoprotein A-I, Apolipoprotein B and Apo B/Apo A-I ratio as cardiovascular risk indicators in patients of Chronic Renal Failure

Abstract

To study the levels of serum lipid profile, serum Apolipoprotein A-I and Apolipoprotein B in patients of Chronic Renal failure and to find out the Apo B/Apo A-I ratio as cardiovascular risk indicator in patients of Chronic Renal Failure. Material and Methods: 45 patients of Chronic Renal failure & 45 healthy controls were studied. Blood samples were analyzed for serum Apolipoprotein A-I and B by Turbidimetric Immunoassay method on automated chemistry analyzer. Unpaired t-test was used to assess the significant difference in the means of the studied variables in the different groups. Results: The mean level of serum apolipoprotein A-I was found to be lower (101.5 ± 13.6 and 130.7 ± 14.2, p <0.0001) and serum apolipoprotein B was higher (126.7 ± 16.6 and 102.9 ± 16.4, p <0.0001) in patients of Chronic Renal Failure when compared with the control group. The mean Apo B/Apo A-I ratio was higher in 82% patients of Chronic Renal Failure compared with the control group (1.27 ± 0.26 and 0.80 ± 0.17, p <0.0001), with normal total cholesterol level in 67% patients and normal LDL level in 64% patients with CRF a nd moderately correlates with S. creatinine levels. Conclusion: Apo B/ Apo A-I ratio is high in patients of Chronic Renal failure and could be an independent risk factor for atherosclerosis and could contribute towards increasing the risk of cardiovascular diseases (CVD) in patients of Chronic Renal failure.