Abstract
Serum and Pancreatic Zinc Levels in Diabetic Rats and Role of Zinc Supplementation on Glycemic Control and Possible Mechanism of Action
Highlights
The prevalence of diabetes is increasing worldwide because of population growth, aging, urbanization, increasing prevalence of obesity and physical inactivity (Ranasinghe et al, 2013)
There were significant reductions (p
Effects of zinc sulfate on alloxan- induced changes: 3.2.1 Blood glucose levels: Zinc sulfate administration in a dose of 100 mg /kg/day orally to diabetic rats did not have any significant effect on mean blood glucose level following 2 weeks of treatment but it caused a significant decrease in blood glucose level after 4 weeks compared to the alloxan treated groups (p
Summary
The prevalence of diabetes is increasing worldwide because of population growth, aging, urbanization, increasing prevalence of obesity and physical inactivity (Ranasinghe et al, 2013). Zinc is one of the most important trace elements in biological systems (Jurowski et al, 2014). It has critical effect in homeostasis, in oxidative stress, and in aging. It is a structural component of key antioxidant enzymes such as superoxide dismutase, which is vital for intra- and extracellular antioxidant defense, and zinc deficiency may impair their synthesis (Zheng et al, 2008). Pancreatic β cells contain the highest amount of zinc among cells within the human body. It is essential in insulin action and carbohydrate metabolism (Chausmer, 1998), and the
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