Abstract
The mechanism of linear growth reduction during GnRHa treatment in central precocious puberty has not been elucidated.
Highlights
The mechanism of linear growth reduction during GnRHa treatment in central precocious puberty has not been elucidated
Aim To investigate the pattern of serum amino-terminal proC-type natriuretic peptide (NT proCNP) in healthy girls throughout puberty, and the changes of serum NT proCNP in girls with idiopathic central precocious puberty (ICPP) before and during gonadotropin-releasing hormone analog(GnRHa) therapy
Linear growth reduction in girls with ICPP treated with GnRHa is due at least in part to decreased CNP mediated long bone growth after estrogen inhibition
Summary
The mechanism of linear growth reduction during GnRHa treatment in central precocious puberty has not been elucidated. Aim To investigate the pattern of serum amino-terminal proC-type natriuretic peptide (NT proCNP) in healthy girls throughout puberty, and the changes of serum NT proCNP in girls with idiopathic central precocious puberty (ICPP) before and during gonadotropin-releasing hormone analog(GnRHa) therapy
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