Abstract
The association between increased serum alkaline phosphatase activity and increased hepatic microsomal-enzyme activity in the beagle has been investigated. Low doses of a combination of ethanol (633 μl/kg/day), propylene glycol (672 μl/kg/day) and chloroform (30 μl/kg/day) raised alkaline phosphatase activities in both serum and liver without concurrently increasing three microsomal enzymes (amidopyrine N-demethylase, p-nitroanisole O-demethylase and benzo[ a]pyrene hydroxylase). Studies with enzyme inhibitors suggested that the increases in hepatic and serum alkaline-phosphatase levels were predominantly due to enzyme of the hepatic type.
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