Abstract
Magnetic nanoparticles (MNPs) have great potential in biochemistry and medical science. In particular, iron oxide nanoparticles have demonstrated a promising effect in various biomedical applications due to their high magnetic properties, large surface area, stability, and easy functionalization. However, colloidal stability, biocompatibility, and potential toxicity of MNPs in physiological environments are crucial for their in vivo application. In this context, many research articles focused on the possible procedures for MNPs coating to improve their physic-chemical and biological properties. This review highlights one viable fabrication strategy of biocompatible iron oxide nanoparticles using human serum albumin (HSA). HSA is mainly a transport protein with many functions in various fundamental processes. As it is one of the most abundant plasma proteins, not a single drug in the blood passes without its strength test. It influences the stability, pharmacokinetics, and biodistribution of different drug-delivery systems by binding or forming its protein corona on the surface. The development of albumin-based drug carriers is gaining increasing importance in the targeted delivery of cancer therapy. Considering this, HSA is a highly potential candidate for nanoparticles coating and theranostics area and can provide biocompatibility, prolonged blood circulation, and possibly resolve the drug-resistance cancer problem.
Highlights
This study presents the mechanism of the below-presented problems and their possible solutions due to albumin protein coating with further surface functionalization
The significant results were obtained using albumin-coated Magnetic nanoparticles (MNPs) loaded with doxorubicin [149], methotrexate [121], curcumin [102,103,145], or synergistic delivery of curcumin with 5-fluorouracil [139], which was shown on the cell line model
Nanoparticles are a promising platform for creating new drugs for simultaneous therapy and diagnostics
Summary
Magnetic nanoparticles (MNPs) open a wide range of applications, including contrast agents area for magnetic resonance imaging (MRI), material science, magnetic delivery, magnetic fluid hyperthermia, structural biology, drug and gene delivery, theranostics [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17]. Such procedures are suitable for multimodal imaging or theranostics smart platforms productions based on MNPs core. Studying MNPs stability and coating procedures opens a doorway for multifunctional and bioinspired material, probes, and devices
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