Serum adipocyte fatty acid-binding protein level is associated with arterial stiffness quantified with cardio-ankle vascular index in kidney transplant patients

Abstract

Arterial stiffness is an established marker of cardiovascular risk and an independent predictor of cardiovascular disease (CVD) events and mortality in kidney transplant (KT) patients. Adipocyte fatty acid-binding protein (A-FABP), a novel adipokine, is positively associated with atherosclerosis. The present study evaluated the relationship between fasting circulating A-FABP and peripheral arterial stiffness using the cardio-ankle vascular index (CAVI) in KT patients. Fasting blood samples were collected from 74 KT patients, and serum A-FABP levels were measured using an enzyme immunoassay. CAVI was calculated using a waveform device (CAVI-VaSera VS-1000). The cutoff values for high and low levels of arterial stiffness were defined by the CAVI values of ≥9 and <9, respectively. Thirty-four patients (45.9%) were classified into the high arterial stiffness group. Compared with the low arterial stiffness group, the high arterial stiffness group had higher values for age (p=0.015), systolic blood pressure (p<0.001), pulse pressure (p<0.001), duration of kidney transplantation (p=0.005), serum total cholesterol and triglyceride levels (p=0.033 and 0.047, respectively), glomerular filtration rate (p=0.019), fasting glucose levels (p=0.012), and serum A-FABP levels (p<0.001). Multivariate forward stepwise linear regression analysis showed that age (p=0.004), systolic blood pressure (p=0.001), and serum A-FABP levels (p=0.003) were independent predictors of CAVI value in KT patients. Serum fasting A-FABP level is positively associated with peripheral arterial stiffness in KT patients.